Nidus MB Technologies offers high-throughput screening solutions using proprietary Microbubble Arrays (MBA™) and microphysiological systems (MPS). Their technology enables _in vitro_ drug discovery and toxicology testing with enhanced cellular microenvironments, supporting the reduction of animal model usage.
Funding
Funding not disclosed
Founders
Product
Problem
Traditional drug discovery and toxicology testing methods often rely on animal models, which can be costly, time-consuming, and may not accurately predict human responses. Existing _in vitro_ screening platforms can also be limited in their ability to replicate complex cellular microenvironments and high-throughput capabilities.
Solution
Nidus MB Technologies provides advanced high-throughput screening (HTS) solutions utilizing proprietary Microbubble Arrays (MBA™) and microphysiological systems (MPS). Our patented Gas Expansion Molding (GEM™) process enables the mass production of arrays with precisely controlled microbubble dimensions, facilitating _in vitro_ drug discovery and toxicology testing with cultured cells, microtissues, and organoids. This technology supports the reduction and refinement of animal model usage in research and development. We offer both catalog products and custom solutions tailored to specific assay requirements, aiming to accelerate the discovery pipeline for novel therapeutics and chemical compounds.
Target Audience
Our primary customers are pharmaceutical companies, biotechnology firms, contract research organizations (CROs), and academic research institutions engaged in drug discovery, toxicology assessment, and cell-based assay development.
Features
- Patented Gas Expansion Molding (GEM™) process for manufacturing Microbubble Arrays (MBA™) with controlled microbubble dimensions and densities.
- MBA™ technology enables high-throughput screening of single cells, microtissues, and organoids for drug discovery and toxicology applications.
- Microbubbles feature spherical architecture and high aspect ratio, concentrating cell-secreted factors to promote rapid media conditioning and _in vitro_ growth.
- MBA™ arrays are compatible with both static culture and microfluidic flow systems, offering flexibility in experimental design.
- IMAAT™ (Image data Acquisition and Analysis Tools) software, coded in Python with convolutional neural networks, provides automated image segmentation for data analysis.
- Applications include monoclonal antibody discovery, cancer cell screening, and the development of tissue chips and microphysiological systems for disease modeling.
- Products are available in various formats, including 2-well, 4-well, 6-well, 12-well, 35mm dishes, 60mm dishes, and 96-well plates, with customizable array densities and microbubble sizes.
- PDMS material offers optical clarity and an elastic modulus similar to soft tissues, favoring anchorage-independent cell growth and _in vivo_ relevance.