This company supplies DNA-PAINT labeling kits and reagents for super-resolution microscopy applications. Their products utilize transient DNA binding for high-resolution imaging with sub-20-nm spatial resolution. They also offer specialized services and collaborations for complex imaging studies.
Funding
Funding not disclosed
Founders
Product
Problem
Conventional super-resolution microscopy techniques are limited by photobleaching and photoswitching of dyes, hindering the ability to achieve high spatial resolution imaging of biological structures over extended periods. Traditional methods also face challenges in multiplexing and achieving sub-nanometer resolution for detailed biomolecule interaction studies.
Solution
Massive Photonics provides DNA-PAINT labeling kits and solutions that enable super-resolution microscopy of proteins and other biological targets. Their technology utilizes short, dye-labeled DNA strands that transiently bind to complementary strands conjugated to affinity reagents, creating a "blinking" effect that allows for high-resolution imaging without photobleaching. The RESI (Resolution Enhancement by Sequential Imaging) technique further enhances resolution, enabling sub-nanometer imaging of biomolecule interactions. Massive Photonics offers a range of kits, including those for primary antibodies, protein tags, and custom reagents, to support diverse research applications.
Target Audience
The primary audience includes researchers in biotechnology and related fields who require high-resolution imaging of cellular structures and protein interactions.
Features
- DNA-PAINT kits for super-resolution imaging with sub-20-nm spatial resolution
- RESI kits enabling sub-nanometer resolution imaging
- No photobleaching or photoswitching of dyes required
- Compatible with standard TIRF microscopes
- Easy spectral multiplexing for imaging multiple targets sequentially
- Kits available for various targets, including primary antibodies, protein tags (e.g., GFP), and custom binders
- qPAINT capabilities for target quantification
- Utilizes Picasso software for image analysis