Klotho Therapeutics is developing recombinant human Klotho proteins to enhance kidney function and mitigate age-related diseases, including cognitive decline and cancer. By targeting the biological mechanisms of aging, their therapy aims to improve healthspan and reduce the incidence of chronic conditions associated with low Klotho levels.
Funding
$10M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Aging is associated with a decline in physiological and cognitive functions, increasing the risk of age-related disorders such as cardiovascular disease, cognitive decline, kidney disease, sarcopenia, and cancer. Current treatments often address individual diseases rather than targeting the underlying aging process.
Solution
Klotho Therapeutics is developing recombinant human Klotho proteins to address age-related diseases by targeting the biological mechanisms of aging. Klotho, a naturally occurring protein, declines with age and is associated with multiple age-related disorders. By supplementing Klotho levels, the therapy aims to improve overall healthspan, enhance kidney function, reduce cognitive decline, suppress tumor growth, and improve resistance to chemotherapy. The recombinant protein is designed to mimic the beneficial effects of natural Klotho, potentially delaying the onset and severity of multiple age-related conditions.
Target Audience
The primary target audience includes individuals at risk of or affected by age-related diseases such as cognitive decline, kidney disease, and cancer, as well as healthcare providers specializing in geriatrics and oncology.
Features
- Recombinant human Klotho protein designed to mimic the effects of naturally produced Klotho.
- Potential to improve kidney function and address symptoms of kidney disease.
- Demonstrated ability in animal studies to suppress tumor growth and inhibit metastases.
- May reduce resistance to chemotherapy drugs and improve survival rates in cancer treatment.
- Designed to address age-related cognitive decline and improve cognitive function.
- Potential to mitigate sarcopenia and improve muscle health.