Traditional RNA sequencing library preparation methods often suffer from low yields and introduce biases, particularly when working with limited RNA input. These limitations can compromise the accuracy and sensitivity of downstream sequencing results, hindering genomics research.

Karnateq offers RNA sequencing library preparation kits that simplify the process and minimize bias, enabling researchers to generate high-quality libraries even from minimal RNA input. Their core technology, Ordered Two-Template Relay (OTTR), utilizes engineered eukaryotic reverse transcriptases in a single-tube workflow. This approach connects 5' and 3' adaptor handles to the RNA or DNA ends during cDNA synthesis, facilitating efficient end-to-end sequence capture. The kits provide a streamlined solution for end-to-end RNA sequence capture, improving the overall efficiency and reliability of RNA sequencing workflows.

OTTR technology for efficient end-to-end sequence capture

Engineered eukaryotic reverse transcriptases for improved performance

Single-tube workflow simplifies library preparation

Compatible with minimal RNA input

Reduces bias in NGS library preparation

Suitable for processed RNA or DNA

Adaptable to various applications, including ribosome profiling and ncRNA sequencing

The primary customers are researchers and scientists in genomics, transcriptomics, and related fields who require robust and reliable RNA sequencing library preparation methods.

Karnateq generates revenue through the sale of OTTR cDNA library construction kits, priced at $1,200 for a 24-reaction kit. Academic and non-profit organizations are eligible for a 30% discount.