IRIS Kinetics provides a label-free, multiplexed microarray platform for precise biomolecular interaction analysis. Its Interferometric Reflectance Imaging Sensor (IRIS) technology measures biomass accumulation via light interferometry, enabling accurate quantification of binding kinetics for drug discovery and diagnostics.
Funding
Funding not disclosed
Founders
Product
Problem
Analyzing biomolecular binding interactions often requires labeling, which can interfere with molecular function, or relies on bulk-effect sensitive methods that are prone to environmental interference. This limits the accuracy and scope of kinetic measurements for applications like drug discovery and diagnostics.
Solution
IRIS Kinetics offers a label-free, multiplexed microarray platform utilizing Interferometric Reflectance Imaging Sensor (IRIS) technology for precise biomolecular interaction analysis. The system measures biomass accumulation on a silicon microarray via light interferometry, detecting changes in oxide thickness as molecules bind. This approach provides high sensitivity and accurate quantification of binding kinetics without the need for labels or susceptibility to bulk effects common in other methods like Surface Plasmon Resonance (SPR). The platform supports a wide range of biological molecules and particles, including small molecules, proteins, nucleic acids, bacteria, and viruses, in various sample matrices like serum and plasma.
Target Audience
The primary users are researchers and developers in drug discovery, biomarker identification, diagnostics, and academic research who require precise, label-free kinetic measurements of biomolecular interactions.
Features
- Label-free detection of biomolecular binding interactions using light interferometry.
- Multiplexed microarray format enabling simultaneous analysis of multiple analytes.
- High sensitivity, achieving sub pg/mL detection limits for proteins.
- Bulk-effect free operation, ensuring accurate kinetic measurements unaffected by buffer composition or solvent changes.
- Rock-stable signal allowing for long-duration measurements to accurately calculate slow dissociation rates.
- Direct thickness measurement of biomass accumulation, providing more accurate quantification than refractive index shifts.
- Compatibility with complex sample matrices, including serum and plasma.
- Low instrument and consumables cost, leveraging silicon wafer production techniques.
- Capability for single-cell imaging and antibiotic susceptibility testing (AST) by monitoring bacterial growth and replication.
- SNP detection through DNA hybridization and denaturation analysis for genotype identification.