Intrinsic Medicine focuses on developing novel therapeutics for serious diseases with high unmet medical need. The company utilizes a proprietary platform to identify and advance small molecule drug candidates. Their pipeline aims to deliver targeted treatments with improved efficacy and safety profiles for patients.
Funding
$5.3M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Current treatments for Gut Immune Microbiome Brain Axis Disorders (GIMBADs) often target single pathways, failing to address the complex interactions between the immune system, nervous system, and gut microbes. Developing safe and effective drugs for GIMBADs is challenging due to the multiple bidirectional pathways involved. Traditional drugs may also have safety concerns and limited efficacy in treating these complex disorders.
Solution
Intrinsic Medicine develops Human-identical milk oligosaccharides (HiMOs) drugs to treat GIMBADs. HiMOs are functionally identical to HMOs found in human milk and offer a multi-faceted approach by promoting beneficial bacteria, suppressing harmful pathogens, demonstrating antiviral activity, regulating immune cells, exerting anti-inflammatory effects, and strengthening the gut epithelial layer. HiMO drugs are stable in stomach acid and resistant to enzyme degradation in the upper GI tract, ensuring their efficacy. The company's approach allows for rapid translation into the clinic with a truncated translational process.
Target Audience
The primary target audience includes individuals suffering from Gut Immune Microbiome Brain Axis Disorders (GIMBADs) and the healthcare providers who treat them.
Features
- HiMO drugs are functionally identical to HMOs, providing a high margin of safety
- Multiple synergistic modes of action targeting the gut-immune-microbiome-brain axis
- Three major HiMO types (neutral, fucosylated, and acidic) with distinct but complementary functions
- Promotes an optimal environment for the proliferation of beneficial bacteria
- Possesses antiviral activity by acting as a decoy receptor
- Regulates both innate and adaptive immune cells
- Local and systemic anti-inflammatory effects
- Strengthens the gut epithelial layer to reduce “leaky gut”