Incircular utilizes the proprietary INCYPRO platform to engineer next-generation therapeutic proteins with enhanced stability and activity. This technology addresses protein degradation challenges that limit the effectiveness of biologics in real-world conditions. The company partners with pharmaceutical firms to accelerate the development of more durable and effective protein-based medicines.
Funding
Funding not disclosed
Founders
Product
Problem
Proteins, essential for biological processes and attractive for various applications, often suffer from instability under process-like conditions, including high temperatures and chemical stressors. This instability leads to structural unfolding, aggregation, reduced functionality, poor performance, and short shelf-life, limiting their usability.
Solution
Incircular addresses protein instability with INCYPRO, a protein engineering technology that stabilizes proteins and protein complexes, enhancing their properties for a range of applications. INCYPRO employs a tris-armed crosslinker to lock the protein structure, maintaining its conformation and function even under challenging conditions. This technology improves protein tolerance to high temperatures, chemical additives, and other stressors, while also stabilizing active protein complexes and conformations. The result is more robust proteins that maintain activity under stress, with minimal modification to the original protein structure.
Target Audience
The primary customers are biotechnology companies and researchers in the pharmaceutical and industrial sectors seeking to improve the stability and functionality of proteins and enzymes for various applications.
Features
- INCYPROsitefinder: AI-driven computational design of triple-cysteine protein variants for optimal crosslinking.
- INCYPROcrosslinkers: Proprietary tris-armed crosslinkers that covalently lock protein structures in place.
- Enhanced thermal stability, allowing proteins to function at higher temperatures.
- Increased tolerance to chemical additives and denaturing agents.
- Stabilization of protein complexes, preserving quaternary structures.
- Activity assays to validate protein function under stressed conditions.
- Biophysical characterization using aggregation tests and stability assays.