ImmuneWatch provides software and services to annotate the epitope specificity of T-cell receptor (TCR) sequences derived from TCR sequencing data. Their platform allows researchers to identify therapy-, vaccine-, or pathogen-specific TCRs, transforming repertoire data into actionable insights for therapeutic development. Additionally, the company offers a reverse vaccinology pipeline to predict and rank immunogenic epitopes from protein or genome inputs.
Funding
Funding not disclosed
Founders
Product
Problem
Analyzing T-cell receptor (TCR) sequencing data to determine epitope specificity is a significant bottleneck in understanding T-cell responses. Current methods for annotating TCR sequences are often slow and lack the ability to translate TCR repertoires into clinically actionable insights. This challenge hinders the development of effective therapeutics and diagnostics that rely on understanding T-cell behavior.
Solution
ImmuneWatch offers a machine learning platform designed to annotate the epitope specificity of TCR sequences, enabling researchers to rapidly identify therapy-, vaccine-, or pathogen-specific TCRs. The platform leverages explainable machine learning algorithms to link TCRs to their cognate epitope sequences, providing insights into T-cell responses. ImmuneWatch's technology is compatible with both single-cell and bulk sequencing approaches, offering a comprehensive solution for analyzing TCR repertoires and accelerating the development of immunotherapies and vaccines. The platform can be run on a user's own infrastructure or through a collaboration with ImmuneWatch.
Target Audience
The primary customers are researchers and organizations involved in developing therapeutics and diagnostics, particularly those focused on immunotherapy, vaccine development, and understanding T-cell responses in various disease contexts.
Features
- Machine learning algorithms that annotate the epitope specificity of TCR sequences.
- Ability to identify therapy-, vaccine-, or pathogen-specific TCRs.
- Compatibility with single-cell and bulk TCR sequencing approaches.
- Immunoinformatic pipelines for complete analysis from FASTQ files to interactive reports.
- Reverse vaccinology pipeline to predict effective vaccine epitopes and antigens.
- Integration with existing research infrastructure or collaboration with ImmuneWatch for analysis.
- Access to a database of TCR-epitope pairings for improved accuracy.