Hologenomix offers the HFX platform, a high‑efficiency cell‑free nucleic acid extraction system that recovers >90 % cfDNA and cfRNA from plasma, urine, and cerebrospinal fluid while preserving fragment integrity. The workflow reduces sample input by up to 80 % and integrates with standard NGS library‑prep and qPCR protocols, supporting automated 96‑well processing. Optional on‑site sequencing and cloud‑based bioinformatics provide QC‑checked variant calls for clinical diagnostics and research.
Funding
Funding not disclosed
Founders
Product
Problem
Conventional cell‑free nucleic acid (cfNA) extraction from biofluids often yields low recovery, requires large sample volumes, and can degrade nucleic acids, limiting the sensitivity and reliability of downstream molecular diagnostics such as liquid biopsies and non‑invasive prenatal testing.
Solution
Hologenomix’s HFX platform delivers a high‑efficiency, cell‑free nucleic acid extraction process that maximizes cfDNA and cfRNA recovery while preserving molecular integrity across a range of biofluid types. The technology reduces the required input volume, lowering per‑sample costs and enabling analysis of scarce clinical specimens. Extracted nucleic acids are compatible with standard library‑preparation workflows, supporting high‑throughput sequencing and quantitative assays. Hologenomix also offers optional sequencing and bioinformatics services, providing end‑to‑end data generation and analysis for diagnostic and research applications. The platform is designed for scalable deployment in clinical laboratories and biotech R&D settings, facilitating rapid adoption of advanced cfNA‑based tests.
Target Audience
Primary customers are clinical diagnostic laboratories, biotech companies, and academic research groups developing cfNA‑based assays for oncology, prenatal screening, infectious disease, transplant monitoring, and neurological disorders.
Features
- Proprietary extraction chemistry achieving >90 % cfNA recovery from plasma, urine, and cerebrospinal fluid
- Sample‑input reduction of up to 80 % compared with conventional kits, decreasing reagent consumption
- Integrated nucleic‑acid integrity preservation to maintain fragment length distribution for accurate downstream quantification
- Compatibility with standard NGS library‑prep kits and quantitative PCR workflows, eliminating protocol redesign
- Automated, high‑throughput workflow capable of processing 96‑well plates with consistent performance
- Optional on‑site sequencing and cloud‑based bioinformatics pipeline delivering QC‑checked variant calls and quantitative reports
- HIPAA‑compliant data handling and secure transfer of raw and processed results