GenNext Technologies offers the Fox® Protein Footprinting System, which utilizes hydroxyl radical protein footprinting (HRPF) to analyze protein higher-order structure and dynamics by assessing solvent accessibility of amino acid side chains. This technology provides biopharmaceutical researchers with critical insights into protein interactions, folding, and stability, enhancing the development of safe and effective biologics.
Funding
$750K raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Biopharmaceutical researchers need to understand protein higher-order structure (HOS) and dynamics to develop safe and effective biologics, but traditional methods for analyzing protein structure can be complex, costly, and may not provide sufficient detail about solvent accessibility and dynamic behavior. Existing techniques may also struggle with a wide range of protein sizes, states, and concentrations.
Solution
GenNext Technologies offers the Fox® Protein Footprinting System, which utilizes hydroxyl radical protein footprinting (HRPF) to analyze protein HOS by assessing the solvent accessibility of amino acid side chains. The system employs hydroxyl radicals to selectively abstract hydrogen atoms from exposed amino acids, inducing the formation of oxidation products that reveal information about protein structure and dynamics. The AutoFox® Protein Footprinting System automates HRPF without requiring expensive lasers, while FoxWare® Software streamlines data processing. This technology provides insights into protein interactions, folding, stability, epitope/paratope mapping, and conformational changes, influencing the safety, efficacy, and quality of biologics.
Target Audience
The primary customers are biopharmaceutical researchers investigating biopharmaceutical structure, interactions, folding, aggregation, formulation, and delivery.
Features
- Automated Hydroxyl Radical Protein Footprinting (HRPF)
- Direct assessment of solvent accessibility
- High spatial resolution
- Compatible with a wide range of protein classes, sizes, states, and concentrations
- Benchtop instrument with user-friendly interface
- Data analysis software tailored for HOS analysis
- Hands-free, high-throughput operation with the AutoFox® system