Gly‑it
Gly-it provides glycosylation services and enzyme kits that let companies modify small molecules to improve properties like solubility, stability, and bioactivity. The company offers a full-service workflow, including assay design, detailed reporting, and scale-up support, plus plasmids for in-house enzyme production. Its UGT enzyme library enables transformations such as di-glycosylation and sugar-on-sugar linkages for pharma, food, and cannabinoid applications.
- Biotechnology
- Chemical Technology
- Healthcare Technology
- New Materials
- Software Only
Funding
Founders
Product
Problem
Many small-molecule drugs, food ingredients, and other compounds suffer from poor solubility, low stability, limited bioavailability, or undesirable toxicity and taste profiles. Chemical modification approaches are often complex, costly, or lack the selectivity needed to achieve targeted improvements in molecular properties.
Solution
Gly-it leverages natural glycosylation enzymes—specifically a library of UGT enzymes—to attach sugar molecules to small-molecule compounds, improving their functional properties. The company offers a full service that begins with a technical consultation to understand the client's program, followed by running assays on the target compound and delivering a detailed report of hits, yields, and improvement recommendations. Clients receive the plasmids needed to produce more enzyme or molecule in-house, and samples of glycosylated molecules can be provided upon request. All services are conducted under confidentiality with no downstream fees or IP claims, giving clients unencumbered ownership of any resulting compositions or use claims.
Target Audience
Primary customers are pharmaceutical, biotech, food ingredient, and cannabinoid companies seeking to improve the properties of small-molecule compounds through enzymatic glycosylation.
Features
- Library of UGT enzymes enabling glycosylation of diverse small molecules, including di-glycosylation and sugar-on-sugar linkages
- Full-service workflow covering consultation, assay design, execution, and detailed reporting on yields and possible improvements
- Supply of plasmids for in-house enzyme and molecule production, supporting scale-up of the glycosylation process
- Capability to provide samples of glycosylated molecules for client evaluation
- Application expertise across multiple sectors, including pharma (improved activity, BBB penetration, reduced toxicity), food (improved taste, solubility), and cannabinoids
- Confidential service model with no downstream fees or IP claims, ensuring unencumbered ownership of results