Gate Bioscience is developing Molecular Gates, small molecule drugs that selectively block disease-causing extracellular proteins from being secreted by targeting the secretory translocon within cells. By preventing the emergence of these harmful proteins, the company aims to eliminate diseases linked to over 1,000 identified extracellular proteins.
Funding
$60M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Many diseases are caused by the secretion of harmful extracellular proteins. Current treatments often address the symptoms of these diseases without targeting the root cause: the production and secretion of these proteins.
Solution
Gate Bioscience is developing Molecular Gates, a novel class of small molecule drugs designed to selectively block the secretion of disease-causing extracellular proteins at their origin within cells. These drugs target the secretory translocon, a channel through which extracellular proteins must pass to be secreted. By binding to the translocon, Molecular Gates prevent specific, disease-causing proteins from being secreted, leading to their degradation and ultimately aiming to eliminate the disease. This approach offers a new therapeutic mechanism for addressing diseases linked to the over 1,000 identified extracellular proteins.
Target Audience
The primary target audience includes researchers and pharmaceutical companies focused on developing treatments for diseases caused by the secretion of harmful extracellular proteins.
Features
- Small molecule drugs that selectively target and block the secretory translocon.
- Mechanism of action prevents the secretion of specific, disease-causing extracellular proteins.
- Targeted proteins are degraded within the cell, preventing them from causing disease.
- Molecular Gate Discovery Platform™ combines a library of Molecular Gates, secretion-focused assays, and expertise in secretory pathway biology.
- Platform enables precise and rapid drug discovery.