Flexomics integrates high-resolution fluorescence microscopy with single-cell genomics to provide a unified platform for analyzing cellular heterogeneity. This approach enables researchers to correlate visual cellular features with genomic data, enhancing the understanding of complex biological systems and accelerating the development of therapeutics.
Funding
Funding not disclosed
Founders
Product
Problem
Current methods in single-cell biology often treat microscopy and sequencing as separate disciplines, limiting the ability to correlate visual cellular features with genomic data. This separation hinders a comprehensive understanding of cellular heterogeneity and slows the development of targeted therapeutics.
Solution
Flexomics offers an integrated platform that combines high-resolution fluorescence microscopy with single-cell genomics, enabling researchers to link visual cellular features with genomic data within a single workflow. The platform utilizes a picowell chip to capture and query live cells, miniaturizing cellular assays for flexible throughput. Fluorescence-based functional data is collected via standard inverted microscopes, followed by cell lysis, nucleic acid capture, barcoding, and processing for sequencing. Single-cell genomic readouts are then correlated back to individual cells, providing a comprehensive view of biological systems.
Target Audience
The primary target audience includes therapeutic companies and researchers in single-cell biology seeking to accelerate the development of high-value biologics and gain deeper insights into cellular function.
Features
- FLEX picowell chip for capturing and querying live cells with high throughput (10,000s to 100,000s of cells)
- Compatibility with standard inverted microscopes for fluorescence-based functional data collection
- Optical cell barcoding strategy compatible with major genomic approaches
- Integrated workflow linking sequencing readouts and imaging-based phenotypic data
- Ability to miniaturize existing cellular assays for increased flexibility