Enrich Biosystems provides the TROVO benchtop instrument for high-throughput functional screening and live-cell retrieval in a fluidics-free system. This platform enables researchers to 3D print hydrogel microwells within standard microplates for long-term imaging of micro-cultures. The system uses AI-enabled tools for analysis, allowing for the selection and retrieval of functional cells based on observed cellular kinetics.
Funding
$4.2M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
BIFounders
Product
Problem
Existing high-throughput cell analysis platforms are expensive and often incapable of studying cell behavior over extended timelines under native conditions. Traditional *in vitro* cell capture technologies require harsh single-cell dissociation methods and cell sorting that can cause stress and damage to the cells.
Solution
Enrich Biosystems' TROVO platform enables high-throughput cell culture and analysis under native conditions, bridging the gap between *in vitro* and *in vivo* analysis. The system utilizes light-based microgel lithography to create up to 24,000 custom microwells within standard cell culture plates, allowing for extended monitoring of cell behavior and minimizing sample loss. TROVO offers two unique modes of cell capture selection: microwell-based capture and free space capture, providing flexibility in experimental design. The platform supports long-term cell culture experiments, enabling researchers to analyze cell kinetics and accurately profile data to identify functional phenotypes. Following visual identification, TROVO can capture and maintain the viability and functionality of desired cells for downstream applications, including NGS and single-cell genomics/transcriptomics analysis.
Target Audience
The primary customers are researchers and scientists in cell biology, immunology, and drug discovery, particularly those focused on cell therapy development, CAR-T cell research, and single-cell omics.
Features
- Light-based microgel lithography and LCD dynamic mask to create up to 24,000 custom microwells in a 6-well culture plate
- Microwell-based capture mode for high-throughput, long-term cell culture experiments
- Free space capture mode for positive, negative, and free form selection of cells
- Open platform compatible with standard cell culture plates and native cell culture conditions
- Visual identification and indexing of wells for downstream data collection and analysis
- Capability to add additional cells during incubation to test functional interactions and phenotypes
- Gentle enzymatic solution for retrieving captured cells without damage
- Compatible with downstream applications such as NGS and single-cell genomics/transcriptomics analysis