Endurazymes
Endurazymes offers EnduraFAST, a commercial screening platform that helps enzyme engineering teams identify which variants remain folded and stable under process-relevant stress conditions like heat, harsh chemistry, and low oxygen. Built on hsFAST reporter technology from Los Alamos National Laboratory, the system uses oxygen-independent, fluorescence-based protein-state readouts to triage large libraries before deeper activity testing.
- Biotechnology
Funding
Founders
Founder details are not available yet.
Product
Problem
Enzyme engineering teams face a bottleneck not in generating variants but in knowing which candidates deserve further investment. As libraries grow, it becomes increasingly difficult to identify which variants remain folded, stable, and useful under the real-world conditions—heat, harsh chemistry, low oxygen, and time—that determine actual performance.
Solution
EnduraFAST gives enzyme teams an earlier way to screen large libraries for candidates worth advancing. The platform lets teams challenge enzyme libraries with process-relevant stress conditions, then uses fluorescence-based protein-state data to identify which variants hold up. Built on hsFAST reporter technology developed at Los Alamos National Laboratory, the system uses folding-dependent, oxygen-independent fluorescence to provide a protein-state readout associated with expression, folding, and stability at elevated temperatures. This commercial screening and triage platform helps teams prioritize candidates that remain folded and stable before committing time, budget, and deeper activity testing.
Target Audience
Primary customers are enzyme engineering teams in industrial biotechnology, pharmaceutical development, and chemical processing who need to screen large variant libraries for stability and durability under process-relevant conditions.
Features
- Fluorescence-based protein-state screening that reports on expression, folding, and stability under stress
- Oxygen-independent fluorescence technology enables testing under low-oxygen and anaerobic conditions
- Multi-condition testing including heat, harsh chemistry, low oxygen, and time-based challenges
- Scalable library screening designed to handle large variant libraries and provide clear triage signals
- Built on hsFAST reporter technology validated in peer-reviewed research from Los Alamos National Laboratory
- Fusion-based readout logic that distinguishes stable from unstable protein behavior under heat stress