Funding
Funding not disclosed
Founders
Product
Problem
Current tissue regeneration approaches rely on in‑vitro cultured patches that must be surgically transplanted, which is invasive and limited by the size and location of defects. Pediatric surgeons also lack readily available, custom surgical instruments, leading to improvised tools that are not widely accessible.
Solution
Endogen Constructs is developing an ultrasonic acoustic holography platform that can assemble bioink particles into tissue patches directly inside the patient’s body, enabling minimally invasive in‑vivo 3D bioprinting across various organ systems. By using sound rather than deposition or light, the technology can reach deeper anatomical sites and scale within the dynamic physiological environment. The company also creates a pipeline for designing simple Class I surgical instruments that can be 3D printed on‑site from FDA‑approved materials, providing a digital repository of pediatric‑focused tool designs. Together, these capabilities aim to expand the range of feasible medical procedures and give clinicians a practical way to produce custom tools and tissue repairs at the point of care.
Target Audience
Primary customers are pediatric and adult surgeons, as well as research labs developing tissue engineering solutions, who need minimally invasive in‑vivo bioprinting capabilities and on‑site custom surgical instruments.
Features
- Ultrasonic acoustic holography system that assembles bioink particles into tissue patches in vivo, eliminating the need for external graft implantation
- Benchtop ultrasonic 3D bioprinter for laboratory evaluation of bioink compatibility and acoustic assembly processes
- Open digital library of 3D‑printable Class I surgical instrument designs tailored for pediatric applications
- Use of FDA‑approved 3D printing materials to enable on‑premise manufacturing of custom surgical tools within hospitals
- Scalable, non‑light‑based printing approach that can access deep tissue sites in a dynamic physiological environment