This startup provides a bisulfite conversion kit that simplifies DNA methylation analysis for epigenomic studies. Their ready-to-use reagent streamlines the process, enabling researchers and clinicians to achieve faster results with enhanced efficiency.
Funding
Funding not disclosed
Founders
Product
Problem
DNA methylation analysis, crucial for epigenomic studies, is often hindered by inefficient bisulfite conversion, leading to DNA damage, incomplete cytosine conversion, and ultimately, inaccurate results. Existing bisulfite conversion kits may suffer from low yields, high degradation rates, and limited compatibility with challenging samples like low-input cell-free DNA.
Solution
Ellis Bio provides bisulfite conversion kits that streamline DNA methylation analysis, improving the accuracy and efficiency of epigenomic studies. Their SuperMethyl™ kits feature an advanced, ready-to-use bisulfite conversion reagent that minimizes DNA damage while ensuring high C-to-T conversion efficiency. The kits are designed for versatile applications, including PCR, methylation-specific PCR (MSP), arrays, library preparation, and next-generation sequencing (NGS). Ellis Bio's technology enables researchers and clinicians to unlock new insights in areas such as cancer detection, aging, and developmental biology.
Target Audience
The primary audience includes researchers and clinicians in epigenomics, cancer research, neuroscience, and developmental biology, particularly those working with challenging samples and low-input DNA.
Features
- Ready-to-use bisulfite conversion reagent for simplified workflow
- Ultrafast conversion, achieving complete bisulfite conversion in under 10 minutes (SuperMethyl™ Fast)
- Optimized chemistry for minimal DNA degradation and high DNA recovery (SuperMethyl™ Max)
- Exceptional C-to-T conversion efficiency, exceeding 99.5%
- Compatibility with low-input DNA samples, validated for 100 pg to 50 ng of cfDNA, gDNA, or FFPE-derived DNA (SuperMethyl™ Max)
- NGS-ready, compatible with major library prep kits and sequencing platforms
- Available in both column and bead-based formats (SuperMethyl™ Fast)