DNTOX GmbH provides animal-free in vitro testing systems utilizing human neural progenitor cells and induced pluripotent stem cells to evaluate the neurotoxic effects of chemicals on brain development. Their technology addresses the need for safe chemical screening by employing advanced multicellular models and AI-driven analysis to assess developmental and adult neurotoxicity.
Funding
$1.5M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
HTFounders
Product
Problem
Traditional chemical safety assessments often rely on animal testing, which raises ethical concerns and may not accurately reflect human biological responses, particularly in the context of neurotoxicity. Evaluating the impact of chemicals on brain development and function requires models that closely mimic human physiology.
Solution
DNTOX GmbH provides animal-free in vitro testing services that utilize human neural progenitor cells (hNPCs) and induced pluripotent stem cells (hiPSCs) to assess the neurotoxic potential of chemicals. Their testing system employs multicellular 2D and 3D cell culture models, including free-floating spheres, plated adherent spheres, and 2D monolayer cultures, to study key neurodevelopmental and neuronal processes. The company leverages machine learning-powered microscopy image and video analysis, along with statistical software, to quantify and evaluate neurotoxicity data. DNTOX offers specialized testing services for developmental neurotoxicity (DNT) and adult neurotoxicity, enabling the identification of compounds that may disrupt brain development or affect neuronal function.
Target Audience
The primary customers are companies in the chemical, pharmaceutical, food, and cosmetics industries seeking reliable and ethical neurotoxicity testing services for regulatory compliance and product safety.
Features
- In vitro developmental neurotoxicity (DNT) testing using multicellular, multiplexed human-based 2D/3D systems
- In vitro adult neurotoxicity testing utilizing 3D hiPSC-derived BrainSpheres differentiated on multi electrode arrays (MEA) to identify neurotransmitter receptor subtypes
- Custom in vitro test method development for specific domains of human development and disease models
- AI-driven analysis of microscopy images and videos for quantitative assessment of neurotoxicity
- Statistical software for DNT data evaluation