DendroTEK offers dPGA, a fully synthetic, protease‑resistant culture matrix that replaces traditional coatings like PLO, PDL, and PEI to improve cell adherence and assay consistency.
Funding
Funding not disclosed
Founders
Product
Problem
Researchers using traditional cell‑culture coatings such as poly‑L‑ornithine (PLO), poly‑D‑lysine (PDL) and polyethylenimine (PEI) often encounter inconsistent cell adherence, clumping, and detachment, especially in long‑term neural assays. These issues reduce assay reliability and increase experimental risk, while the coatings’ protein or animal origins raise reproducibility concerns.
Solution
DendroTEK provides dPGA, a fully synthetic, protease‑resistant dendritic polyglycerol amine matrix that can replace PLO, PDL and PEI in cell‑culture protocols. The product is supplied as a sterile, ready‑to‑use concentrated stock solution with a water‑like viscosity that dissolves readily in water or PBS and remains stable for up to two years. By preventing cell clumping and lifting, dPGA improves monolayer uniformity and enhances the performance of imaging‑based and electrophysiological assays, particularly for iPSC‑derived motor and midbrain neurons. Its 100 % protein‑ and animal‑component‑free composition supports reproducible results across laboratories and reduces the need for frequent re‑coating. The matrix’s protease resistance ensures long‑term stability of cell attachment during media changes and extended culture periods.
Target Audience
Primary customers are academic and industry research laboratories that culture neural cells, especially those working with iPSC‑derived neurons, electrophysiology (MEA) platforms, and high‑throughput imaging assays.
Features
- Fully synthetic dendritic polyglycerol amine, eliminating protein and animal contaminants
- Protease‑resistant surface that maintains cell attachment during prolonged culture and media changes
- Water‑like viscosity; soluble in water and PBS for easy preparation
- Sterile, ready‑to‑use concentrated stock solution with a shelf life of up to two years
- Prevents cell clumping and lifting, yielding uniform monolayers for consistent assay readouts
- Compatible with a range of neural cell types, including iPSC‑derived motor and midbrain neurons, and suitable for imaging, lysosomal enzyme, and multi‑electrode array (MEA) experiments