The startup operates a biotechnology platform that utilizes proprietary DNA and protein sequence databases to filter and annotate genetic variant data. This technology enables researchers to accurately identify genetic changes responsible for inherited diseases, enhancing drug development and gene therapy efforts.
Funding
$960K raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Traditional methods of genetic variant analysis often suffer from population biases and provide limited insight into protein function, leading to uncertainty in variant classification and hindering the development of effective therapies. Researchers need more comprehensive tools to accurately interpret genetic variations and their impact on human health.
Solution
Cornerstone Genomics offers CodeXome, a genomic research platform that leverages a proprietary database of primate evolutionary data to provide a population-agnostic analysis of genetic variants. By integrating data from over 55 primate genera, CodeXome enables researchers to reclassify variants of uncertain significance, predict protein function, and identify potential therapeutic targets with greater precision. The platform's evolutionary genomics approach transcends the limitations of traditional population-based methods, offering a more meaningful interpretation of genetic variants. CodeXome integrates seamlessly into existing research workflows, providing robust data and analysis tools to enhance research from start to finish. Researchers can upload VCF files, cross-reference data with major genomic databases, and analyze the evolutionary history of variants to predict their impact on protein function.
Target Audience
The primary target audience includes researchers in disease genomics, functional genomics, and biomedical genomics, particularly those focused on rare diseases, oncology, and target validation.
Features
- Proprietary database of 80 million years of primate evolution, offering unparalleled evolutionary context.
- Population-agnostic analysis based on evolutionary history, eliminating biases found in traditional genomic studies.
- Real-time reclassification of Variants of Uncertain Significance (VUS) using current evolutionary data.
- Comprehensive gene and protein analysis, providing a holistic view of genetic function.
- Evolutionary histogram mapping how 19,000 genes evolve across 80 million years.
- Data upload compatible with Variant Call Format (VCF) files aligned with the human reference genome (HG38).
- Cross-referencing with major genomic databases like gnomAD, UniProt, and ClinVar.
- Prediction of variant impact on protein function, identifying changes that may be benign, pathogenic, or therapeutically significant.