Paul Mead
Paul Mead

Develops the CoFI System, a medical device that diagnoses microvascular obstruction (MVO) in real-time during percutaneous coronary interventions (PCI) using existing guide catheters and wires. It provides rapid, accurate detection of MVO, a condition affecting up to 60% of acute heart attack patients, and enables controlled delivery of therapeutic agents directly into the vasculature to improve patient outcomes.
Raised to date
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Paul Mead
Microvascular obstruction (MVO) is a frequent complication, occurring in up to 60% of acute heart attack patients, where small blood vessels in the heart become blocked, potentially leading to tissue death and adverse outcomes. Current methods for detecting MVO, such as cardiac magnetic resonance (CMRI), are not routinely utilized early in the management of acute heart attack patients. Failure to detect and treat MVO can lead to re-hospitalization with heart failure or other major adverse cardiac events.
CorFlow's Controlled Flow Infusion (CoFI) System is designed to diagnose MVO in real-time during percutaneous coronary interventions (PCI) using existing guide catheters and wires. The CoFI System rapidly delivers microvascular diagnostic information, seamlessly fitting into the PCI workflow. It also enables controlled delivery of therapeutic agents directly into the vasculature. By accurately detecting MVO and providing a platform for targeted drug delivery, the CoFI System aims to improve cardiac patient outcomes and expand physician treatment capabilities.
The primary users are interventional cardiologists and medical professionals involved in the treatment of acute heart attack patients undergoing PCI procedures.