COBO Technologies offers quality control services for CRISPR genome editing, providing precise DNA mutation analysis and proteome expression profiling. Their platforms ensure the accuracy and reliability of gene editing experiments, supporting therapeutic development and genetic engineering research.
Funding
Funding not disclosed
Founders
Product
Problem
Ensuring the precision and reliability of CRISPR genome editing applications is critical for therapeutic development and genetic engineering research. Inaccurate assessment of DNA mutations and protein expression can lead to flawed experimental outcomes and hinder the advancement of gene editing technologies.
Solution
COBO Technologies provides specialized quality control services for CRISPR genome editing applications, addressing the need for precise validation of gene modifications. Their proprietary platforms offer detailed DNA mutation analysis and comprehensive proteome expression profiling to ensure the accuracy and reliability of gene editing experiments. By delivering quantitative data on indel formation and protein level changes, COBO Technologies supports researchers in validating their CRISPR strategies. This enables the advancement of CRISPR-based therapeutic development and genetic engineering research by providing confidence in experimental results.
Target Audience
The primary customers are researchers and scientists in academic institutions, biotechnology companies, and pharmaceutical firms engaged in gene editing research and the development of CRISPR-based therapeutics.
Features
- **CRISPR InDel Profiling Platform (CIPP™):** Utilizes the IDAA method for quantitative analysis of insertions and deletions (InDels) in gene-edited cells, capable of detecting down to single base changes and large deletions up to 1000 base pairs.
- **ProfileIt™ Software:** A one-click InDel analysis software designed for high-throughput sample analysis, providing detailed statistics on InDel percentages, out-of-frame InDels, and publication-quality profile images.
- **Proteome Expression Platform (PIPPR):** Employs SWATH LC-MS for label-free proteome-wide identification and quantification of over 6,000 proteins, enabling confirmation of target protein knockouts and assessment of unexpected protein expression changes.
- **PIPPR Pathway Analysis:** Offers detailed analysis of protein expression across pathways and gene families, facilitating the assessment of safety and efficacy of gene editing modifications.
- **CoboXtract™:** A rapid, one-tube DNA extraction solution designed for PCR-ready DNA suitable for fragment analysis applications like the IDAA method, optimized for high-throughput workflows.
- **On-/Off-Target Services:** Comprehensive service offering including InDel profiling, amplicon sequencing, and proteome analysis for complete validation of CRISPR modifications.
- **Bioinformatics Support:** Provides NGS data analysis and specialized software for InDel analysis, supporting the interpretation of complex genomic data.