Clareo Biosciences provides complete and precise adaptive immune receptor sequencing to reveal how genetic variation shapes B and T cell function in health and disease. Its technology characterizes both antigen-binding and signaling domains at the DNA and RNA level, enabling direct links between an individual's genetics and immune receptor behavior. This supports improved disease diagnosis, treatment response prediction, and vaccine design.
Funding
Funding not disclosed
Founders
Product
Problem
Current immune profiling technologies lack the resolution needed to fully characterize adaptive immune receptors at both the DNA and RNA level. As a result, links between immune function, disease pathology, and clinical outcomes are rarely reported, even though these connections exist but remain invisible to existing tools.
Solution
Clareo Biosciences offers complete immune repertoire sequencing, enabling characterization of antibody and T cell receptor domains that correspond to both antigen interaction and intracellular signaling functions. By sequencing immune receptor genes at the DNA level, the company is the first to allow direct links between immune receptor transcript characterization and an individual's genetic makeup. This holistic approach reveals how genetic variation dictates antibody and T cell receptor function, illuminating critical differences in why some people get sick or respond better to particular treatments and vaccines. The resulting data helps better understand disease pathologies, improve diagnoses, and design more effective treatments and vaccines.
Target Audience
Primary customers are researchers, clinicians, and biopharmaceutical companies studying immune-related diseases, developing diagnostics, or designing vaccines and immunotherapies that require high-resolution immune repertoire characterization.
Features
- Complete repertoire sequencing covering both antigen-binding and signaling domains of antibodies and T cell receptors
- DNA-level sequencing of immune receptor genes to link personalized genetics to receptor function
- Accurate discrimination of antibody and TCR-encoding genes and alleles, including antigen-associated clonal lineages, binding domains, and somatic hypermutation profiles
- Resolution of antibody isotype/subisotype and constant domain allelic variation to link effector function with antigen binding domains
- Transparent data analysis workflows and deliverables for downstream interpretation