Cascade develops cell-free biocatalysts using proprietary immobilization technology to enhance enzyme performance and longevity. Their silica-bead stabilized enzymes offer a wider operating window and increased output for use in chemical, pharmaceutical, and food industries. This platform enables cost-efficient, reusable biocatalysis to streamline chemical manufacturing processes.
Funding
Funding not disclosed
TDFounders
Product
Problem
Industrial enzymes often exhibit limited operational stability, requiring harsh conditions or frequent replacement, which increases process costs and reduces efficiency. This instability hinders their broader adoption in demanding chemical manufacturing environments.
Solution
Cascade provides cell-free biocatalysts engineered for enhanced performance and longevity through proprietary enzyme immobilization technology. These biocatalysts are stabilized on silica beads, creating a protective "body armor" that significantly extends enzyme lifespan and allows them to operate under a wider range of conditions. This robust formulation enables seamless integration into existing industrial workflows, offering a more sustainable and cost-effective alternative to traditional chemical synthesis or less stable enzymatic processes. Cascade's approach unlocks the potential for biology to drive efficient molecular production across diverse sectors.
Target Audience
Target customers include companies in the food, chemical, waste management, and pharmaceutical industries seeking to improve the efficiency and sustainability of their manufacturing processes through advanced biocatalysis.
Features
- Enzyme immobilization on silica beads for enhanced mechanical and chemical stability.
- Proprietary "Body Armor" technology that cushions enzymes, improving resilience to temperature, solvents, and pH variations.
- Covalent immobilization enabling multiple reuses of the biocatalyst, reducing overall enzyme consumption.
- Porogen-free silica-based materials, ensuring suitability for food and pharmaceutical applications.
- Low leaching of enzymes from the support matrix, maintaining product purity.
- Low non-specific absorption, facilitating efficient recovery of the desired end product.
- Customizable resin formats, including 1.5mm beads and sub-100µm particles, for compatibility with various process equipment.
- Demonstrated 100% success rate in improving enzyme stability across 17 different enzyme types.