Capacity Bio develops small molecules, peptides, and nanoparticles that enhance the identification and clearance of dysfunctional mitochondria through the activation of mitophagy pathways. This approach addresses the accumulation of suboptimal mitochondria in cells, which contributes to increased reactive oxygen species and cell death during aging and disease.
Funding
$35M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
During aging and disease, cells often struggle to identify and remove dysfunctional mitochondria, leading to an accumulation of suboptimal mitochondria. This accumulation results in increased reactive oxygen species (ROS), inflammatory signals, decreased ATP production, and ultimately, cell death. Current strategies to safely and effectively target mitophagy, the process by which dysfunctional mitochondria are removed, remain challenging.
Solution
Capacity Bio is developing small molecules, peptides, and nanoparticles designed to enhance the identification of dysfunctional mitochondria and activate mitophagy pathways. Their approach promotes the clearance of these damaged mitochondria by autophagosomes and lysosomes, thereby addressing the root cause of cellular dysfunction. By improving the cell's ability to remove and replace dysfunctional mitochondria, Capacity Bio aims to reduce ROS production, decrease inflammation, and improve overall cellular health. This targeted approach has the potential to address a wide range of age-related and other diseases linked to mitochondrial dysfunction.
Target Audience
Capacity Bio's primary target audience includes pharmaceutical companies and research institutions focused on developing therapies for age-related diseases, neurodegenerative disorders, and other conditions linked to mitochondrial dysfunction.
Features
- Development of small molecule mitophagy agonists
- Peptide-based mitophagy enhancers
- Nanoparticle delivery systems for targeted mitophagy activation
- Focus on enhancing the identification of dysfunctional mitochondria
- Activation of autophagosome-mediated clearance of damaged mitochondria
- Modulation of mitochondrial biogenesis to maintain optimal mitochondrial mass