BioThrust develops the Membrane Stirrer technology for bioreactors, enabling bubble-free gas transfer and minimal shear stress during cell cultivation. This approach significantly increases cell yield and process efficiency across various cell types, addressing the challenges of traditional bioreactor systems that often damage cells and limit scalability.
Funding
Funding not disclosed
EAFounders
Product
Problem
Traditional stirred-tank bioreactors often damage cells due to bubble aeration and high shear stress, limiting cell yield and scalability, especially for sensitive cell types and 3D cell cultures. Existing systems struggle to maintain homogeneous culture conditions and efficient gas transfer without compromising cell viability.
Solution
BioThrust offers the ComfyCell bioreactor, which utilizes a novel Membrane Stirrer technology to enable bubble-free gas transfer and minimal shear stress during cell cultivation. This approach increases cell yield and process efficiency across various cell types, including organoids, iPSCs, MSCs, and viral vectors. The system's design ensures homogeneous mixing and precise process control, leading to consistent product quality and facilitating linear scale-up from 100 mL to 200 L. The Membrane Stirrer gently mixes the media while providing cells with necessary gases and nutrients, avoiding cell damage associated with conventional stirred-tank reactors.
Target Audience
The primary target audience includes researchers and manufacturers in cell therapy, regenerative medicine, and biopharmaceutical industries who require efficient and scalable cell culture systems for sensitive cell types and advanced applications.
Features
- Membrane Stirrer technology for bubble-free aeration and low shear stress
- CFD-optimized system design for homogeneous cultivation conditions across all volumes
- High kLa rates for efficient gas transfer and CO2 stripping
- Compatible with various cell types, including suspension cells, adherent cells on microcarriers, and spheroids
- Suitable for cell expansion, differentiation processes, and in-situ perfusion (in development)
- Available in reusable and single-use formats
- Scalable from 250 mL to 200 L