biomodal develops the duet multiomics solution evoC, which captures both genetic and epigenetic data from a single 5ng DNA sample in one sequencing run, enabling the analysis of 5-methylcytosine and 5-hydroxymethylcytosine alongside the four canonical bases. This technology addresses the limitations of current sequencing methods that fail to provide comprehensive insights from low-input samples, enhancing applications in cancer research, neurodegenerative disease, and precision medicine.
Funding
Funding not disclosed
Founders
Product
Problem
Current sequencing technologies often fail to comprehensively analyze both genetic and epigenetic data from low-input DNA samples, resulting in incomplete biological insights. Existing methods struggle to reliably resolve the four canonical DNA bases alongside modified cytosines like 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in a single experiment.
Solution
Biomodal's duet multiomics solutions, including evoC and +modC, enable simultaneous genetic and epigenetic sequencing from a single, low-input DNA sample. The evoC solution captures the 6-base genome, distinguishing 5mC and 5hmC alongside the four canonical bases, providing a comprehensive view of genomic and epigenomic modifications. This integrated approach enhances biomarker discovery and validation, offering transformative insights into disease mechanisms and potential therapeutic targets. By combining genetic and epigenetic analysis in a single sequencing run, researchers can dissect complex biological processes and gain a deeper understanding of normal and disease biology. The duet multiomics solutions streamline workflows, reduce sample requirements, and improve the accuracy of multiomic data.
Target Audience
The primary target audience includes life scientists and clinical developers in fields such as cancer research, neurodegenerative disease, and precision medicine, seeking to enhance their understanding of disease mechanisms through integrated genomic and epigenomic analysis.
Features
- Simultaneous analysis of genetic and epigenetic data from a single 5ng DNA sample
- Discrimination of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) alongside the four canonical bases
- High-resolution methylation profiling for enhanced disease characterization
- Compatibility with existing sequencing infrastructure
- Streamlined pre-sequencing workflow with post-sequencing informatics
- Applications in cancer research, neurodegenerative disease, liquid biopsy, aging, and precision medicine
- Potential for novel multimodal biomarker discovery and validation