Amplitude Vascular Systems has developed Pulse IVL™, an intravascular lithotripsy system that utilizes high-frequency pulsatile pressure waves to fracture arterial calcium and restore blood flow in patients with severely calcified arterial disease. This technology enhances deliverability and efficiency, providing healthcare providers with a reliable tool to improve patient outcomes in vascular treatments.
Funding
$45.2M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Severely calcified arterial disease presents a significant challenge in vascular treatments, limiting blood flow and hindering effective restoration through conventional methods. Current treatment options often struggle with deliverability and efficiency in heavily calcified lesions, leading to suboptimal patient outcomes.
Solution
Amplitude Vascular Systems addresses this challenge with Pulse IVL™, an intravascular lithotripsy system designed to fracture arterial calcium using high-frequency pulsatile pressure waves. This system enhances deliverability, allowing it to navigate complex and calcified lesions more effectively. The unique mechanism of action converts pressurized CO2 into pulsatile energy waves, radiating uniformly along the balloon's length at a rate of 15 pulses per second. By fracturing calcium in a multi-directional manner while expanding the vessel, Pulse IVL™ facilitates improved blood flow and provides healthcare providers with a more efficient tool for treating severely calcified arterial disease. The system is being evaluated for use in peripheral, coronary, and carotid arteries.
Target Audience
The primary target audience includes interventional cardiologists, vascular surgeons, and other healthcare providers specializing in the treatment of peripheral artery disease and other vascular conditions involving severely calcified lesions.
Features
- High-frequency pulsatile pressure waves to fracture arterial calcium
- Enhanced deliverability for navigating complex and calcified lesions
- Unique mechanism of action converting pressurized CO2 into pulsatile energy
- Uniform, multi-directional radiation of energy waves along the balloon's length
- Full-thickness calcium fractures achieved in diseased arteries
- Effective luminal expansion in both concentric and eccentric lesions