Avant Genomics automates cell-free DNA sample preparation for liquid biopsy with its Avant Source™ cartridge-based system, replacing 50+ manual steps with a closed, benchtop workflow. The platform delivers 65% higher cfDNA yield and 70% lower cost per sample while reducing hands-on time to just five minutes. The system runs up to 12 cartridges in parallel, each pre-loaded with reagents and engineered to minimize contamination and sample loss.
Funding
Funding not disclosed
Founders
Product
Problem
Liquid biopsy sample preparation remains a largely manual process, requiring 50+ hands-on steps that introduce variability and reduce recovery of tumor-derived cell-free DNA. This inconsistency compromises the reliability and sensitivity of downstream genomic analysis, limiting the clinical utility of blood-based cancer detection and monitoring.
Solution
Avant Source™ is a fully automated, cartridge-based sample preparation system that standardizes cfDNA extraction and purification from plasma. The enclosed cartridge integrates isolation, enrichment, transfer, purification, and elution into a single closed workflow, eliminating manual pipetting and open-tube handling. The benchtop instrument runs up to 12 cartridges in parallel, each pre-loaded with reagents and engineered surfaces that minimize cfDNA loss. The system achieves 65% higher cfDNA yield and 70% lower cost per sample compared to conventional semi-automated methods, with only five minutes of hands-on time required.
Target Audience
Primary customers are clinical laboratories, molecular diagnostics companies, and oncology research institutions that perform liquid biopsy testing and require reliable, scalable cfDNA sample preparation for cancer detection and monitoring.
Features
- Fully enclosed, self-contained cartridge with pre-loaded reagents and internal waste capture, eliminating open-tube handling and contamination risk
- Size-selective cfDNA enrichment that concentrates the tumor-derived fraction before sequencing, improving detection of rare ctDNA
- Parallel processing of up to 12 samples per run with compatibility for both EDTA and Streck tube blood collection formats
- Engineered cartridge surfaces that minimize cfDNA binding and loss compared to standard plastic labware
- Integrated fluidics that reduce transfer loss and variability across all workflow stages
- Benchtop instrument designed for routine clinical use with minimal operator training