ArteraNova’s NanoSmooth™ platform is a peptide‑nanoparticle drug‑coated balloon that delivers targeted restorative therapy directly into the vessel wall during angioplasty. 8% in preclinical models.
Funding
Funding not disclosed
Founders
Product
Problem
Standard drug‑coated balloons used in vascular interventions release cytotoxic agents that indiscriminately suppress cell growth, damaging healthy endothelium and impairing natural vessel healing. This non‑specific injury often necessitates prolonged anticoagulant therapy and leads to higher rates of restenosis and repeat procedures.
Solution
ArteraNova’s NanoSmooth™ platform employs a peptide‑nanoparticle drug‑coated balloon to deliver a targeted restorative therapy directly into the vessel wall during angioplasty. The nanoparticle carrier enhances tissue penetration and enables sustained, localized release of selective peptide agents that inhibit smooth‑muscle cell migration while preserving endothelial regeneration. By decoupling maladaptive smooth‑muscle proliferation from protective endothelial healing, the system reduces intimal thickening and minimizes systemic exposure, offering a safer alternative to conventional cytotoxic coatings and decreasing reliance on long‑term blood thinners.
Target Audience
Primary customers are interventional cardiologists, vascular surgeons, and medical device manufacturers seeking advanced drug‑coated balloon solutions for coronary, peripheral artery disease, and in‑stent restenosis applications.
Features
- Peptide‑nanoparticle formulation that achieves three‑fold higher therapeutic accumulation in the arterial wall compared with traditional coatings
- High‑penetration nanoparticle delivery ensures deep tissue uptake and sustained peptide release for extended therapeutic windows
- Selective inhibition of smooth‑muscle cell migration (60% reduction) while maintaining endothelial cell health
- Demonstrated 63.8% reduction in intimal thickening in preclinical models, indicating strong anti‑restenosis efficacy
- Localized delivery minimizes off‑target systemic exposure, improving safety profile
- Compatible with standard balloon angioplasty catheters for seamless integration into existing interventional workflows