Armonica develops proprietary long-read DNA sequencing technology that enables real-time sequencing of ultra-long, native nucleic acid molecules without the need for amplification or labeling. This technology addresses critical gaps in genomic analysis by accurately detecting large structural variants and epigenetic modifications that traditional methods often miss.
Funding
$4.1M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
NHFounders
Product
Problem
Current next-generation sequencing (NGS) technologies often fail to detect critical epigenetic modifications and large structural variants, leading to incomplete genomic analysis and diagnostic gaps. Existing methods require amplification and labeling, which can introduce bias and errors, especially when analyzing long DNA fragments.
Solution
Armonica develops a long-read DNA sequencing platform that enables real-time analysis of native, ultra-long nucleic acid molecules without amplification or labeling. The technology utilizes proprietary nanochannel structures and surface-enhanced Raman spectroscopy (SERS) to directly detect nucleotide sequences and epigenetic modifications at single-base resolution. By eliminating amplification and directly sequencing long DNA fragments, the platform overcomes limitations of traditional NGS methods, providing more comprehensive and accurate genomic information. This approach facilitates the detection of structural variants, long-range epigenetic mapping, and de novo genome assembly.
Target Audience
The primary target audience includes researchers, diagnostic labs, and pharmaceutical companies involved in genomics research, drug development, and precision medicine who require comprehensive and accurate detection of genomic variants and epigenetic modifications.
Features
- Direct sequencing of native DNA molecules longer than 50 kbp
- Real-time, single-base resolution without amplification or labeling
- Proprietary nanochannel technology for DNA linearization and velocity control
- Surface-enhanced Raman spectroscopy (SERS) for direct nucleotide and epigenetic modification detection
- Detection of structural variants, epigenetic modifications, and haplotype phasing
- Potential for de novo whole genome assembly with reduced computational resources
- Minimal sample preparation and reduced reagent consumption