Aperiam Bio develops hyperfolding variants of proteins that significantly enhance expression, solubility, and specific activity, enabling the production of stable enzymes for various applications. Their technology addresses the instability of natural proteins in harsh conditions, ensuring over 68% activity retention in therapeutics and extending the shelf life of cosmetic ingredients.
Funding
$9M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
OVFounders
Product
Problem
Many natural proteins are unstable and lose activity when exposed to harsh conditions or during manufacturing processes, limiting their use in therapeutics, cosmetics, and technical reagents. This instability hinders the development of effective enzyme-based products and restricts the application of natural proteins in various industries.
Solution
Aperiam Bio develops hyperfolding protein variants with significantly enhanced expression, solubility, and specific activity. Their technology identifies stabilizing mutations in target proteins, resulting in variants that exhibit improved performance and stability. These designer proteins enable the production of stable enzymes suitable for use as technical reagents, cosmetic ingredients, and pulmonary biologics, even under challenging conditions.
Target Audience
The primary customers are companies in the therapeutics, cosmetics, and technical reagent industries seeking stable and high-performing protein variants for product development and manufacturing.
Features
- Hyperfolding technology that enhances protein expression, solubility, and specific activity by tenfold or more.
- Computer vision algorithms to identify stabilizing mutations in target proteins.
- Stable enzymes for cosmetic applications that remain active for months.
- Pulmonary biologics that retain over 68% activity after nebulization.
- Improved manufacturing economics for producing previously inaccessible technical reagents.