Alpenglow Biosciences provides a 3D pathology platform that utilizes Hybrid Open Top Light Sheet (HOTLS) microscopy and AI analysis to deliver high-resolution imaging of biological samples. This technology enables researchers to visualize complex tissue structures and cellular distributions, enhancing drug development and clinical diagnostics by revealing insights that traditional 2D histology methods cannot capture.
Funding
$6.8M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
NIFounders
Product
Problem
Traditional 2D histology methods limit researchers' ability to visualize complex tissue structures and cellular distributions within biological samples. These limitations hinder comprehensive understanding in drug development and clinical diagnostics, obscuring insights that could be revealed through a more complete, three-dimensional view.
Solution
Alpenglow Biosciences offers a 3D pathology platform that combines advanced tissue preparation, Hybrid Open Top Light Sheet (HOTLS) microscopy, and AI-powered analysis to provide high-resolution imaging of entire biological samples. The HOTLS technology enables optical sectioning from mesoscopic to sub-micron scales while preserving specimen integrity for downstream molecular assays. This end-to-end solution allows researchers to visualize convoluted shapes, complex cell distributions, sparse objects, and entire structures, uncovering insights impossible or impractical with 2D methods. The platform includes cloud-based processing and storage, 3D visualization tools, and a suite of analytical tools to facilitate comprehensive 3D image analysis.
Target Audience
The primary users are pharmaceutical companies, clinical research organizations, and academic institutions involved in drug development and clinical diagnostics.
Features
- Advanced sample preparation techniques to accelerate thick tissue labeling in 3D and advanced clearing methods
- Hybrid Open Top Light Sheet (HOTLS) imaging platform for high-throughput optical sectioning from mesoscopic to sub-micron scales
- Open-top design enabling simultaneous accommodation of dozens to hundreds of samples
- GPU-accelerated processing for rapid 3D image reconstruction
- Comprehensive 3D image analysis tools for visualizing and quantifying tissue structures and cellular distributions
- AI-powered analysis to uncover deep insights and reveal previously unseen patterns
- Cloud-based processing and storage for secure data management and collaboration
- Custom 3D-printed holders to ensure optimal imaging quality