Aelius Biotech develops integrated in vitro gastrointestinal models that simulate digestion, mucus permeation, and epithelial absorption to facilitate the development of orally delivered products. Their technology enables companies to make data-driven decisions early in the product development process, reducing risks and costs associated with traditional testing methods.
Funding
$633.1K raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Developing orally delivered products is challenging due to the complex barriers within the gastrointestinal tract, including digestion, mucus permeation, and epithelial absorption. Traditional testing methods often fail to accurately predict how formulations will behave in vivo, leading to costly late-stage failures and delays in product development. Animal testing raises ethical concerns and may not fully translate to human physiology.
Solution
Aelius Biotech offers integrated in vitro gastrointestinal models that simulate the digestive, mucus, and epithelial barriers to provide comprehensive insights into the behavior of orally delivered products. These models enable early-stage, data-driven decision-making, reducing the risks and costs associated with traditional testing approaches. By integrating digestion, mucus permeation, and epithelial absorption into a single system, Aelius Biotech provides a more accurate and predictive assessment of product performance. The Aelius Formulation Toolkit equips researchers with the tools needed to select, design, optimize, and improve formulations, accelerating the development process and increasing the likelihood of successful market entry.
Target Audience
Aelius Biotech serves pharmaceutical companies, food and beverage manufacturers, and research institutions involved in developing orally delivered products, functional foods, and nutritional supplements.
Features
- Integrated model gut systems capable of modeling digestion, mucus permeation, and epithelial absorption in a single system.
- Predictive lab models simulating the entire digestive tract, from mouth to large intestine.
- Cell culture systems for gastrointestinal and airway research, including air-liquid interface models and access to primary cell culture sources.
- Mucus interaction studies to analyze permeation, rheology, and cell interactions.
- Bioactive screening and testing using enzyme, nutrient, and biomarker assays.
- Nutrient analysis services for identifying and quantifying compounds of interest in foods, formulations, and biological samples.
- Toxicology/cell damage assessments using integrated mucus-cell models to characterize cytotoxicity.
- HPLC and other analytical methods for comprehensive sample analysis.
- Rheology and viscosity measurements for materials analysis.
- BITE (Benchmarking Ingredient for Tolerability and Efficacy) trials for human trial services.