The startup develops a non-volatile, non-toxic glyoxal fixative that provides optimal tissue fixation at both structural and molecular levels, enabling pathologists and histologists to preserve cellular components effectively. This alternative to formalin maintains equivalent histological efficacy while ensuring a safer working environment.
Funding
$2.7M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Formalin, a widely used tissue fixative in histology, poses significant health risks due to its carcinogenic, toxic, and mutagenic properties, creating safety concerns for healthcare professionals and environmental disposal challenges. Current regulatory landscapes increasingly restrict formalin use, necessitating safer alternatives that maintain diagnostic accuracy and efficacy in tissue preservation.
Solution
Addax Biosciences offers Glyoxal Acid-Free (GAF), a non-volatile and non-toxic glyoxal-based fixative solution designed as a direct replacement for formalin in histology. GAF ensures optimal tissue fixation at both structural and molecular levels, preserving cellular components, antigens, proteins, and nucleic acid sequences without the health and environmental hazards associated with formalin. Validated through extensive trials and clinical collaborations, GAF demonstrates equivalent or superior histological efficacy compared to formalin, enabling accurate diagnoses while improving workplace safety and reducing disposal costs. GAF supports various applications, including immunohistochemistry, next-generation sequencing, and veterinary pathology.
Target Audience
The primary target audience includes pathologists, histologists, laboratory technicians, and veterinary professionals seeking a safer and equally effective alternative to formalin for tissue fixation in hospitals, research institutions, and veterinary clinics.
Features
- Non-carcinogenic and non-toxic composition, ensuring a safer working environment
- Equivalent or superior tissue fixation compared to formalin, validated by histological, immunohistochemical, and molecular analyses
- Compatible with various downstream applications, including IHC, NGS, and molecular profiling
- Improved DNA and RNA quality in fixed tissues, enhancing the reliability of genomic analysis
- Suitable for both human and veterinary pathology applications
- Reduces technical, procedural, and organizational costs associated with formalin handling and disposal
- Compliant with EU regulations restricting formalin use