Bruker Spatial Genomics provides instrumentation and assays for direct in situ visualization of the 3D genome architecture within single cells. Their PaintScape platform utilizes jebFISH technology to enable high-plex, high-resolution imaging of chromosome structure and organization. This capability allows researchers to trace individual chromosome homologs and gain insights into genome organization relevant to cell programming and disease mechanisms.
Funding
Funding not disclosed
Founders
Product
Problem
Understanding the spatial organization of the genome within individual cells is crucial for deciphering gene regulation and cellular function, but current methods lack the resolution and throughput needed for comprehensive analysis. Traditional techniques often require destructive methods or are limited in their ability to visualize the 3D genome structure in situ. This hinders the ability to study complex biological processes and develop targeted therapies.
Solution
Acuity Spatial Genomics offers OligoFISSEQ, a platform for visualizing and analyzing the 3D organization of the genome within individual cells. This technology enables researchers to study genome architecture and chromatin structure directly in situ, providing insights into genomic organization. By combining combinatorial labeling, in situ sequencing, and advanced imaging, OligoFISSEQ allows for high-resolution mapping of genomic loci and chromatin interactions. The platform provides a comprehensive view of the spatial relationships between genes, regulatory elements, and other genomic features, facilitating a deeper understanding of gene expression, cellular differentiation, and disease mechanisms.
Target Audience
The primary users are researchers in academia and the pharmaceutical industry studying gene regulation, genome architecture, and cellular function in the context of development, disease, and therapeutic response.
Features
- High-resolution 3D visualization of genome organization within single cells
- In situ sequencing-based technology for direct mapping of genomic loci
- Combinatorial labeling approach for multiplexed detection of genomic elements
- Compatibility with various sample types, including cells and tissues
- Advanced image analysis tools for quantitative analysis of genomic architecture