The startup has developed a collagen-targeting technology that specifically binds to unfolded collagen chains, enabling the identification and analysis of diseases characterized by high collagen remodeling. This technology produces proprietary collagen peptides that facilitate extensive laboratory applications in biomechanics and regenerative medicine.
Funding
$3.8M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Current methods for detecting and analyzing collagen remodeling in diseases often lack specificity and sensitivity, making it difficult to accurately assess the extent of collagen damage. Traditional techniques can be time-consuming, labor-intensive, and may not effectively differentiate between healthy and degraded collagen.
Solution
3Helix provides collagen hybridizing peptides (CHPs) that specifically bind to unfolded collagen chains, enabling precise identification and quantification of collagen denaturation in both in vitro and in vivo applications. These CHPs, sharing the Gly-X-Y repeating sequence of natural collagen, hybridize with denatured collagen fragments, offering a targeted approach for studying diseases characterized by high collagen remodeling. The technology facilitates applications in biomechanics, regenerative medicine, diagnostics, and histopathology, allowing for improved disease diagnosis, staging, and evaluation of therapeutic candidates.
Target Audience
The primary customers include researchers in biomechanics and regenerative medicine, histopathologists, and diagnostic laboratories focused on diseases involving collagen remodeling, as well as personal care companies.
Features
- High-affinity binding to denatured collagen, providing specificity in detection
- Applicable to a wide range of tissue types and medical areas, including cardiology, dermatology, hepatology, oncology, ophthalmology and pulmonology
- Can be used in SDS-PAGE gels for facile, sensitive, and specific collagen detection, avoiding Western blot steps
- Available with various conjugates, including 5-FAM, Biotin, Cy3, and sulfo-Cy7.5 for diverse applications
- Suitable for in vitro and in vivo studies
- Can be used as a stain for collagen in highly denatured tissues, offering higher specificity than conventional collagen stains