10x Genomics offers an end‑to‑end platform for high‑throughput single‑cell and spatial genomics, combining Chromium X instruments, Flex Apex multiplexing, and universal 3′/5′ chemistries to profile gene expression, protein markers, and other molecular features from diverse sample types. Integrated software tools such as Cell Ranger, cloud‑based analysis, and the Loupe Browser automate data processing and visualization, enabling researchers to scale from pilot studies to large projects with high sensitivity and reproducibility.
Funding
Funding not disclosed
Founders
Product
Problem
Researchers need to profile gene expression, protein markers, and other molecular features at single‑cell resolution across a wide variety of sample types, including fresh, frozen, FFPE, and fixed whole blood. Existing workflows are often inflexible, require large batches, and lack integrated analysis tools, limiting the scale and speed of discovery in fields such as oncology, immunology, and drug development.
Solution
10x Genomics provides a suite of Chromium X series instruments and GEM‑X chemistry that automate cell partitioning, barcoding, and library preparation for single‑cell and spatial genomics assays. Their Flex Apex platform enables plate‑based multiplexing of up to 384 samples per week, supporting archival and low‑quality specimens. Universal 3′ and 5′ assays deliver whole‑transcriptome coverage with optional multi‑omic extensions (protein, CRISPR, TCR/BCR, ATAC). Integrated software—including Cell Ranger pipelines, cloud‑based analysis, and the Loupe Browser—processes data from raw reads to interactive visualizations without requiring bioinformatics expertise. The end‑to‑end workflow—from optimized sample prep through one‑day library generation to intuitive downstream analysis—allows researchers to scale from pilot studies to large‑scale projects while maintaining high sensitivity and reproducibility.
Target Audience
Primary customers are academic and industry researchers in genomics, immunology, oncology, and drug discovery who require high‑throughput single‑cell or spatial profiling of diverse sample types, as well as pharmaceutical teams seeking robust, scalable assays for biomarker identification and therapeutic development.
Features
- Chromium X instruments generate >10,000 Gel Beads‑in‑Emulsion (GEMs) per run, achieving up to 80 % cell capture efficiency and >95 % usable reads
- Flex Apex plate‑based multiplexing supports 96‑well formats, enabling processing of up to 384 samples or 100 M cells per week with partial‑plate flexibility
- Universal 3′ and 5′ chemistries provide whole‑transcriptome coverage plus optional multi‑omic modules (cell‑surface protein, intracellular protein, CRISPR sgRNA capture, TCR/BCR sequencing, ATAC)
- Probe‑based Flex assays target >18,000 coding genes with three‑fold coverage, optimized for FFPE, fixed whole blood, and other low‑quality samples
- One‑day workflow: <4 h hands‑on time from sample to sequencing‑ready library, with automated partitioning and barcoding
- Free Cell Ranger pipelines for on‑prem processing and 10x Genomics Cloud Analysis for scalable, accelerated computation
- Interactive Loupe Browser for visualization, cell‑type annotation, differential expression, and spatial data exploration