In the production of therapeutic proteins, enzymes, and food products, misfolding and aggregation of proteins during purification leads to significant economic losses, reduced product quality, and potential safety concerns. Traditional refolding methods often rely on high energy consumption and harsh chemicals, posing environmental and sustainability challenges.

ReProteinAll offers a protein purification technology based on patented soft nanopores that detect and refold misfolded proteins, mitigating aggregation during downstream processing. The technology employs a low-pressure brushing mechanism within the nanopores to gently "massage" proteins into their correct conformation. This process enhances the quality, safety, and efficacy of proteins while significantly reducing energy consumption and eliminating the need for harmful chemicals. The technology is inspired by natural chaperonin complexes and uses engineered pores with specialized coatings to prevent proteins from sticking together, improving yields and reducing costs.

Patented soft nanopore technology for detecting and refolding misfolded proteins.

Low-pressure brushing mechanism to guide proteins towards their correct structure.

Selective capture of misfolded proteins via hydrophobic interactions within the nanopores.

High-throughput processing for efficient protein purification.

Demonstrated recovery of up to 70% of misfolded and aggregated proteins.

Potential reduction of associated production costs by up to 71%.

Sustainable process with up to one million times less energy consumption compared to traditional methods.

The primary target audience includes companies in the food, pharmaceutical, and chemical industries involved in the production of recombinant proteins, therapeutic proteins, enzymes, cultured meat, vegan products, monoclonal antibodies, insulin, biofuels, and recyclable plastics.